After losing her sister to an overdose, Chief Superintendent Jo Howe is desperate to tackle the world of drugs that consumes the shadowy backstreets of Brighton. Operation Eradicate is her response but not everyone sees it as a positive development. For self-made millionaire Sir Ben Parsons it is a threat to his business - his colossal empire relies on addicts who survive on Respite Pharmaceuticals' substitute drugs. With connections in the highest levels of government, media and organised crime, Parsons unleashes a brutal counterattack on Howe.